There are a number of people—I certainly am one of them—who strenuously object to being unwilling medical guinea pigs in the matter of the COVID-19 vaccines.
I'm all for medical research, worked as part of a medical research team, and have been a willing human guinea pig in a few experiments myself. This work, when done carefully, knowledgeably, and ethically, is an essential part of scientific and medical advancement. But the ethically part is essential, and I don't think it's ethical to "enroll" masses of people in experiments for which there cannot possibly be adequate knowledge of the risks, and thus they cannot possibly give "informed consent." Plus, when there is no documented, adequate control group, not to mention that the experimenters have done their best to make sure there cannot be an adequate control group—well, then you've lost good science as well as ethics.
You're thinking I'm talking about the COVID-19 vaccines here, and I am—but that's not all. I don't know how many times we've been unknowingly subjected to these unethical experiments, but I do know that it has happened at least two other times in my lifetime.
Aspirin used to be the standard, go-to medication for children, even babies, with fevers or discomfort. I vividly remember the doctor recommending alternating doses of aspirin and acetaminophen when my infant daughter had a stubborn high fever. This was in the early 1980's, and for most people it worked just great. However, there appeared to be a possible correlation between aspirin use in children and young teens, in combination with a viral illness (often chicken pox), and a rare but sometimes fatal condition called Reye Syndrome. We had many doctors among our coworkers, and had no reason not to believe what they told us at the time: The decision to tell doctors and parents to avoid giving aspirin to children was a deliberate, national experiment: They thought aspirin caused Reye's Syndrome in children, but they couldn't prove it, so they hoped that if aspirin use went down dramatically, and so did the incidence of Reye, their point would be made. The disorder did, indeed, retreat significantly, whether through causation or merely correlation is still unknown. The cynic in me insists on pointing out that, whatever the stated reasons for this massive non-laboratory experiment, and whatever good might or might not come of it, one clear result was that a cheap, readily-available, and highly effective drug was massively replaced by one still under patent. The patent for acetaminophen (Tylenol) did not expire until 2007, and Tylenol was still reeling from the 1982 poisoned-Tylenol-capsules scare. Practically overnight, and with timing highly favorable to the pharmaceutical industry, Tylenol became the drug of choice for a large segment of the population.
The next example I remember of such a huge, non-controlled experiment happened in the early 1990's, and was not a drug but a parenting practice: the insistence by the medical profession that all babies never be allowed to sleep on their stomachs. Sleep position recommendations have flip-flopped several times over the years. The professionals never think it safe to leave that decision up to the babies and their parents, they just keep changing what it is that is "the only safe way for a baby to sleep." Personally, I think "whatever helps the baby sleep best" is almost always the right choice. (But I am not a doctor, nor any other medical professional, so make your own choices and don't sue me.)
Early in the 1990's the thought was that back-sleeping might reduce the incidence of Sudden Infant Death Syndrome (SIDS). Indeed, there was a decline after the "Back to Sleep" push went into effect, though once again the experiment was unscientific with no significant control group. Certainly there were still parents who put their babies to sleep on their stomachs, but if there was any widespread study of them I never heard of it, and indeed the data was necessarily corrupted because the pressure was so great not to do so that few parents talked openly about it. And doctors, even if they were well aware of the advantages of stomach-sleeping, could not risk mentioning them to their patients. I remember vividly the one young mother who, months later, confessed to the pediatrician that her son had always slept on his stomach. The doctor laughed, saying, "Of course I knew that! Look at how advanced he is, and look at the perfect shape of his head!" But stomach-sleeping is still very much a "don't ask, don't tell" situation.
These massive, uncontrolled, and to my mind unethical experiments on the human population are justified in the minds of many because, after all, they "did their job." Deaths from Reye Syndrome, SIDS, and COVID-19 have all fallen, so who cares how we got there?
Well, I care—and so should anyone who believes in the scientific method, the Hippocratic Oath, and open, honest, and ethical research.